Ontology highlight
ABSTRACT:
SUBMITTER: Chao F
PROVIDER: S-EPMC6269743 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Chao Fan F Wang Dong-En DE Liu Rui R Tu Qin Q Liu Jian-Jun JJ Wang Jinyi J
Molecules (Basel, Switzerland) 20130510 5
A series of new matrinic acid derivatives 5a-e was synthesized. The chemical structures of the synthesized compounds were confirmed by ¹H-NMR, ¹³C-NMR, and electrospray ionization mass spectroscopy. The anti-tumor activities were also investigated in vitro by evaluating the effect of synthesized compounds on the proliferation of A375, A549, HeLa, and HepG2 cells. Compound 5e was found to be the most potent against A375 and HeLa cells, with IC₅₀ values of 37 and 75.5 μg/mL, respectively. Compound ...[more]