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A new triterpenoid from Teucrium viscidum.

ABSTRACT: A new ursane-type triterpenoid, 3?-hydroxy-urs-30-p-Z-hydroxycinnamoyloxy-12-en-28-oic-acid (1), together with three known triterpenoids, 3?-hydroxy-urs-30-p-E-hydroxycinnamoyloxy-12-en-28-oic-acid (2), 2?,3?,19?-trihydroxy-urs-12-en-28-oic-acid (3), and ursolic acid (4), four known lignans, pinoresinol (5), 9?-hydroxypinoresinol (6), (+)-medioresinol (7), and (+)-kobusin (8), and two steroids, ?-sitosterol (9), and daucosterol (10), were isolated from the whole parts of Teucrium viscidum. Their structures were established by a combination of spectroscopic data analysis, besides comparison with literature data. Compounds 1-4 were evaluated for their inhibitory activities against 11?-hydroxysteroid dehydrogenase 1 (11?-HSD1).

SUBMITTER: Hao X

PROVIDER: S-EPMC6270140 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature

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A new triterpenoid from Teucrium viscidum.

Hao Xincai X Zhang Jinwen J Xia Guangxin G Xue Yongbo Y Luo Zengwei Z Si Yanyan Y Yao Guangmin G Zhang Yonghui Y

Molecules (Basel, Switzerland) 20130121 1

A new ursane-type triterpenoid, 3β-hydroxy-urs-30-p-Z-hydroxycinnamoyloxy-12-en-28-oic-acid (1), together with three known triterpenoids, 3β-hydroxy-urs-30-p-E-hydroxycinnamoyloxy-12-en-28-oic-acid (2), 2α,3β,19α-trihydroxy-urs-12-en-28-oic-acid (3), and ursolic acid (4), four known lignans, pinoresinol (5), 9α-hydroxypinoresinol (6), (+)-medioresinol (7), and (+)-kobusin (8), and two steroids, β-sitosterol (9), and daucosterol (10), were isolated from the whole parts of Teucrium viscidum. Their ...[more]

PMID: 23337296

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