Ontology highlight
ABSTRACT:
SUBMITTER: Chavan AS
PROVIDER: S-EPMC6270175 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20130227 3
The direct nucleophilic addition of alkyl amines to the α(δ')-carbon atom of dimethyl (E)-hex-2-en-4-ynedioate to generate α,β-dehydroamino acid derivatives is reported. Herein, we have studied the reactivity of various primary and secondary alkyl amines in the α-selective nucleophilic conjugate addition to conjugated dimethyl (E)-hex-2-en-4-ynedioate. The reaction with primary alkyl amines gives only the (2E,4E)-stereoisomer, while that with secondary alkyl amines gives the (2E,4E) and (2Z,4E)- ...[more]