Ontology highlight
ABSTRACT:
SUBMITTER: Russo S
PROVIDER: S-EPMC6270184 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Russo Simonetta S Incerti Matteo M Tognolini Massimiliano M Castelli Riccardo R Pala Daniele D Hassan-Mohamed Iftiin I Giorgio Carmine C De Franco Francesca F Gioiello Antimo A Vicini Paola P Barocelli Elisabetta E Rivara Silvia S Mor Marco M Lodola Alessio A
Molecules (Basel, Switzerland) 20131021 10
The Eph-ephrin system plays a critical role in tumor growth and vascular functions during carcinogenesis. We had previously identified cholanic acid as a competitive and reversible EphA2 antagonist able to disrupt EphA2-ephrinA1 interaction and to inhibit EphA2 activation in prostate cancer cells. Herein, we report the synthesis and biological evaluation of a set of cholanic acid derivatives obtained by conjugation of its carboxyl group with a panel of naturally occurring amino acids with the ai ...[more]