Ontology highlight
ABSTRACT:
SUBMITTER: Jawalekar AM
PROVIDER: S-EPMC6270431 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20130624 7
Copper-free click chemistry between cyclooctynes and azide is a mild, fast and selective technology for conjugation of oligonucleotides. However, technology for site-specific introduction of the requisite probes by automated protocols is scarce, while the reported cyclooctynes are large and hydrophobic. In this work, it is demonstrated that the introduction of bicyclo[6.1.0]nonyne (BCN) into synthetic oligonucleotides is feasible by standard solid-phase phosphoramidite chemistry. A range of phos ...[more]