Ontology highlight
ABSTRACT:
SUBMITTER: Fiebig JE
PROVIDER: S-EPMC6270503 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Fiebig Juliane E JE Weidauer Stella E SE Qiu Li-Yan LY Bauer Markus M Schmieder Peter P Beerbaum Monika M Zhang Jin-Li JL Oschkinat Hartmut H Sebald Walter W Mueller Thomas D TD
Molecules (Basel, Switzerland) 20130925 10
Bone Morphogenetic Proteins (BMPs) are secreted protein hormones that act as morphogens and exert essential roles during embryonic development of tissues and organs. Signaling by BMPs occurs via hetero-oligomerization of two types of serine/threonine kinase transmembrane receptors. Due to the small number of available receptors for a large number of BMP ligands ligand-receptor promiscuity presents an evident problem requiring additional regulatory mechanisms for ligand-specific signaling. Such a ...[more]