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Ulososides and urabosides--triterpenoid saponins from the Caribbean marine sponge Ectyoplasia ferox.


ABSTRACT: Three new triterpene glycosides, named ulososide F (1), urabosides A (2) and B (3), together with the previously reported ulososide A (4), were isolated from the Caribbean marine sponge Ectyoplasia ferox. Their structures were elucidated using extensive interpretation of 1D and 2D-NMR data, as well as HRESIMS. The aglycon of all compounds is a rare 30-norlonastane and the sugar residues were identified after acid hydrolysis and GC analyses. Cytotoxicities of the isolated compounds were evaluated against Jurkat and CHO cell lines by a MTT in vitro assay as well as a hemolysis assay. Unexpectedly, all these saponin derivatives showed very low activity in our bioassays.

SUBMITTER: Colorado J 

PROVIDER: S-EPMC6270507 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature

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Ulososides and urabosides--triterpenoid saponins from the Caribbean marine sponge Ectyoplasia ferox.

Colorado Jhonny J   Muñoz Diana D   Marquez Diana D   Marquez Maria Elena ME   Lopez Juan J   Thomas Olivier P OP   Martinez Alejandro A  

Molecules (Basel, Switzerland) 20130227 3


Three new triterpene glycosides, named ulososide F (1), urabosides A (2) and B (3), together with the previously reported ulososide A (4), were isolated from the Caribbean marine sponge Ectyoplasia ferox. Their structures were elucidated using extensive interpretation of 1D and 2D-NMR data, as well as HRESIMS. The aglycon of all compounds is a rare 30-norlonastane and the sugar residues were identified after acid hydrolysis and GC analyses. Cytotoxicities of the isolated compounds were evaluated  ...[more]

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