Ontology highlight
ABSTRACT:
SUBMITTER: Maeda S
PROVIDER: S-EPMC7034192 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Maeda Shoji S Qu Qianhui Q Robertson Michael J MJ Skiniotis Georgios G Kobilka Brian K BK
Science (New York, N.Y.) 20190501 6440
Muscarinic acetylcholine receptors are G protein-coupled receptors that respond to acetylcholine and play important signaling roles in the nervous system. There are five muscarinic receptor subtypes (M1R to M5R), which, despite sharing a high degree of sequence identity in the transmembrane region, couple to different heterotrimeric GTP-binding proteins (G proteins) to transmit signals. M1R, M3R, and M5R couple to the G<sub>q/</sub> <sub>11</sub> family, whereas M2R and M4R couple to the G<sub>i ...[more]