Ontology highlight
ABSTRACT:
SUBMITTER: Oledzka E
PROVIDER: S-EPMC6270997 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Oledzka Ewa E Horeglad Paweł P Gruszczyńska Zuzanna Z Plichta Andrzej A Nałęcz-Jawecki Grzegorz G Sobczak Marcin M
Molecules (Basel, Switzerland) 20141125 12
Camptothecin-polylactide conjugates (CMPT-PLA) were synthesized by covalent incorporation of CMPT into PLA of different microstructure, i.e., atactic PLA and atactic-block-isotactically enriched PLA (Pm = 0.79) via urethane bonds. The kinetic release of CPMT from CMPT-PLA conjugates, tested in vitro under different conditions, is possible in both cases and notably, strongly dependent on PLA microstructure. It shows that release properties of drug-PLA conjugates can be tailored by controlled desi ...[more]