Ontology highlight
ABSTRACT:
SUBMITTER: Forezi Lda S
PROVIDER: S-EPMC6271384 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20140522 5
As part of a continuing search for new potential anticancer candidates, we describe the synthesis, cytotoxicity and mechanistic evaluation of a series of 4-oxoquinoline-3-carboxamide derivatives as novel anticancer agents. The inhibitory activity of compounds 10-18 was determined against three cancer cell lines using the MTT colorimetric assay. The screening revealed that derivatives 16b and 17b exhibited significant cytotoxic activity against the gastric cancer cell line but was not active agai ...[more]