Two new coumarins from Talaromyces flavus.

ABSTRACT: Two new coumarins, talacoumarins A (1) and B (2), were isolated from the ethyl acetate extract of the wetland soil-derived fungus Talaromyces flavus BYD07-13. Their structures were elucidated by spectroscopic data (NMR, MS) analyses. The absolute configuration of C-12 in 1 was assigned using the modified Mosher's method, whereas that of C-12 in 2 was deduced via the circular dichroism data of its corresponding [Rh2(OCOCF3)4] complex. Compounds 1 and 2 were evaluated for their anti-A?42 aggregation, cytotoxic, and antimicrobial activities. The results showed that the two compounds had moderate anti-A?42 aggregation activity, and this is the first report on the A?42 inhibitory aggregation activity of coumarins.

SUBMITTER: He JW 

PROVIDER: S-EPMC6271517 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature