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An efficient synthesis of pyridoxal oxime derivatives under microwave irradiation.

ABSTRACT: Quaternary salts of pyridoxal oxime have been synthesized by the quaternization of pyridoxal oxime with substituted phenacyl bromides using microwave heating. Microwave-assisted rapid synthesis was done both in solvent (acetone) and under solvent-free conditions. Good to excellent yields (58%-94%) were obtained in acetone in very short reaction times (3-5 min) as well as in the solvent-free procedure (42%-78%) in very short reaction times (7-10 min) too. Effective metodologies for the preparation of pyridoxal oxime quaternary salts, having the advantagies of being eco-friendly, easy to handle, and performed in shorter reactions time are presented. The structure of compound 7, in which a 4-fluorophenacyl moiety is bonded to the pyridinium ring nitrogen atom, was unequivocally confirmed by the single-crystal X-ray diffraction method.

SUBMITTER: Gaso-Sokac D

PROVIDER: S-EPMC6271574 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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An efficient synthesis of pyridoxal oxime derivatives under microwave irradiation.

Gašo-Sokač Dajana D Bušić Valentina V Cetina Mario M Jukić Marijana M

Molecules (Basel, Switzerland) 20140606 6

Quaternary salts of pyridoxal oxime have been synthesized by the quaternization of pyridoxal oxime with substituted phenacyl bromides using microwave heating. Microwave-assisted rapid synthesis was done both in solvent (acetone) and under solvent-free conditions. Good to excellent yields (58%-94%) were obtained in acetone in very short reaction times (3-5 min) as well as in the solvent-free procedure (42%-78%) in very short reaction times (7-10 min) too. Effective metodologies for the preparatio ...[more]

PMID: 24914903

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