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HFIP-Promoted Bischler Indole Synthesis under Microwave Irradiation.

ABSTRACT: 1,1,1,3,3,3-Hexafluoropropan-2-ol (HFIP) was found to be effective for the Bischler indole synthesis under microwave irradiation in the absence of a metal catalyst. Under the catalysis of HFIP, a wide range of ?-amino arylacetones were successfully transformed into indole derivatives with moderate to good yields.

SUBMITTER: Yao G

PROVIDER: S-EPMC6321335 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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HFIP-Promoted Bischler Indole Synthesis under Microwave Irradiation.

Yao Guangkai G Zhang Zhi-Xiang ZX Zhang Cheng-Bei CB Xu Han-Hong HH Tang Ri-Yuan RY

Molecules (Basel, Switzerland) 20181214 12

1,1,1,3,3,3-Hexafluoropropan-2-ol (HFIP) was found to be effective for the Bischler indole synthesis under microwave irradiation in the absence of a metal catalyst. Under the catalysis of HFIP, a wide range of α-amino arylacetones were successfully transformed into indole derivatives with moderate to good yields. ...[more]

PMID: 30558133

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