Ontology highlight
ABSTRACT:
SUBMITTER: Kwiecien A
PROVIDER: S-EPMC6271600 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Kwiecień Anna A Barys Maciej M Ciunik Zbigniew Z
Molecules (Basel, Switzerland) 20140730 8
Under neutral conditions the reactions between 4-amino-1,2,4-triazole and cyano-substituted benzaldehyde derivatives yield stable hemiaminals. Addition of small amounts of acid catalyst promotes further step of dehydration resulting in formation of Schiff bases. Four new hemiaminals and the corresponding imines have been obtained. The molecular stability of the hemiaminal intermediates results from both the 1,2,4-triazole moiety and electron withdrawing substituents on the phenyl ring, so no fur ...[more]