Ontology highlight
ABSTRACT:
SUBMITTER: Chazin Ede L
PROVIDER: S-EPMC6272564 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Chazin Eliza de Lucas Ede L Sanches Paola de Souza Pde S Lindgren Eric Brazil EB Vellasco Júnior Walcimar Trindade WT Pinto Laine Celestino LC Burbano Rommel Mario Rodríguez RM Yoneda Julliane Diniz JD Leal Kátia Zaccur KZ Gomes Claudia Regina Brandão CR Wardell James Lewis JL Wardell Solange Maria Silva Veloso SM Montenegro Raquel Carvalho RC Vasconcelos Thatyana Rocha Alves TR
Molecules (Basel, Switzerland) 20150127 2
With the aim of discovering new anticancer agents, we have designed and synthesized novel 6-hydroxy-benzo[d][1,3]oxathiol-2-one Schiff bases. The synthesis started with the selective nitration at 5-position of 6-hydroxybenzo[d][1,3]oxathiol-2-one (1) leading to the nitro derivative 2. The nitro group of 2 was reduced to give the amino intermediate 3. Schiff bases 4a-r were obtained from coupling reactions between 3 and various benzaldehydes and heteroaromatic aldehydes. All the new compounds wer ...[more]