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Tyrosine sulfation as a protein post-translational modification.


ABSTRACT: Integration of inorganic sulfate into biological molecules plays an important role in biological systems and is directly involved in the instigation of diseases. Protein tyrosine sulfation (PTS) is a common post-translational modification that was first reported in the literature fifty years ago. However, the significance of PTS under physiological conditions and its link to diseases have just begun to be appreciated in recent years. PTS is catalyzed by tyrosylprotein sulfotransferase (TPST) through transfer of an activated sulfate from 3'-phosphoadenosine-5'-phosphosulfate to tyrosine in a variety of proteins and peptides. Currently, only a small fraction of sulfated proteins is known and the understanding of the biological sulfation mechanisms is still in progress. In this review, we give an introductory and selective brief review of PTS and then summarize the basic biochemical information including the activity and the preparation of TPST, methods for the determination of PTS, and kinetics and reaction mechanism of TPST. This information is fundamental for the further exploration of the function of PTS that induces protein-protein interactions and the subsequent biochemical and physiological reactions.

SUBMITTER: Yang YS 

PROVIDER: S-EPMC6272617 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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Tyrosine sulfation as a protein post-translational modification.

Yang Yuh-Shyong YS   Wang Chen-Chu CC   Chen Bo-Han BH   Hou You-Hua YH   Hung Kuo-Sheng KS   Mao Yi-Chih YC  

Molecules (Basel, Switzerland) 20150128 2


Integration of inorganic sulfate into biological molecules plays an important role in biological systems and is directly involved in the instigation of diseases. Protein tyrosine sulfation (PTS) is a common post-translational modification that was first reported in the literature fifty years ago. However, the significance of PTS under physiological conditions and its link to diseases have just begun to be appreciated in recent years. PTS is catalyzed by tyrosylprotein sulfotransferase (TPST) thr  ...[more]

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