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Microwave-Assisted Condensation Reactions of Acetophenone Derivatives and Activated Methylene Compounds with Aldehydes Catalyzed by Boric Acid under Solvent-Free Conditions.

ABSTRACT: We here disclosed a new protocol for the condensation of acetophenone derivatives and active methylene compounds with aldehydes in the presence of boric acid under microwave conditions. Implementation of the reaction is simple, healthy and environmentally friendly owing to the use of a non-toxic catalyst coupled to a solvent-free procedure. A large variety of known or novel compounds have thus been prepared, including with substrates bearing acid or base-sensitive functional groups.

SUBMITTER: Brun E

PROVIDER: S-EPMC6272727 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Microwave-Assisted Condensation Reactions of Acetophenone Derivatives and Activated Methylene Compounds with Aldehydes Catalyzed by Boric Acid under Solvent-Free Conditions.

Brun Elodie E Safer Abdelmounaim A Carreaux François F Bourahla Khadidja K L'helgoua'ch Jean-Martial JM Bazureau Jean-Pierre JP Villalgordo Jose Manuel JM

Molecules (Basel, Switzerland) 20150623 6

We here disclosed a new protocol for the condensation of acetophenone derivatives and active methylene compounds with aldehydes in the presence of boric acid under microwave conditions. Implementation of the reaction is simple, healthy and environmentally friendly owing to the use of a non-toxic catalyst coupled to a solvent-free procedure. A large variety of known or novel compounds have thus been prepared, including with substrates bearing acid or base-sensitive functional groups. ...[more]

PMID: 26111185

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