Ontology highlight
ABSTRACT:
SUBMITTER: Palaniraja J
PROVIDER: S-EPMC6273232 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Palaniraja Jeyakannu J Mohana Roopan Selvaraj S Mokesh Rayalu G G Abdullah Al-Dhabi Naif N Valan Arasu Mariadhas M
Molecules (Basel, Switzerland) 20161118 11
This study deals with a new and efficient metal-free regioselective synthesis of pyrimido-fused indazoles with nitrogen ring junction motifs. We have developed a metal-free domino type reaction between 3-aminoindazole, aryl aldehydes and aceotophenones in the presence of KOH/DMF that leads to pyrimido[1,2-<i>b</i>]indazole analogues. Response Surface Methodology (RSM) coupled with a Box-Behnken design (BBD) were utilized for exploring the effect of base used (A), temperature of reaction (B) and ...[more]