Ontology highlight
ABSTRACT:
SUBMITTER: Wang HC
PROVIDER: S-EPMC6273578 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Wang Hai-Chao HC Yan Xiao-Qiang XQ Yan Tian-Long TL Li Hong-Xia HX Wang Zhong-Chang ZC Zhu Hai-Liang HL
Molecules (Basel, Switzerland) 20160803 8
A series of novel benzohydrazide derivatives containing dihydropyrazoles have been synthesized as potential epidermal growth factor receptor (EGFR) kinase inhibitors and their biological activities as potential antiproliferative agents have been evaluated. Among these compounds, compound H20 exhibited the most potent antiproliferative activity against four cancer cell line variants (A549, MCF-7, HeLa, HepG2) with IC50 values of 0.46, 0.29, 0.15 and 0.21 μM respectively, which showed the most pot ...[more]