Ontology highlight
ABSTRACT:
SUBMITTER: Wei H
PROVIDER: S-EPMC6273768 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Wei Huiqiang H Li Deguan D Yang Xiangbo X Shang Haihua H Fan Saijun S Li Yiliang Y Song Dan D
Molecules (Basel, Switzerland) 20161214 12
Sixteen novel epidermal growth factor receptor (EGFR)/vascular endothelial growth factor (VEGF)-2 inhibitors (nitroimidazole-substituted 4-anilinoquinazoline derivatives (<b>16a</b>-<b>p</b>)) were designed and prepared via the introduction of a nitroimidazole group in the piperidine side chain and modification on the aniline moiety of vandetanib. Preliminary biological tests showed that comparing with vandetanib, some target compounds exhibited excellent EGFR inhibitory activities and anti-prol ...[more]