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A Versatile Axle for the Construction of Disassemblage Rotaxanes.

ABSTRACT: Rotaxanes are unique mechanical devices that hold great promise as sensors. We report on two new rotaxanes that contain an acid or base sensitive trigger and readily disassemble in a wide range of environments. Disassemblage was observed under TLC and ¹H-NMR analysis. The axle is highly charged, which enhances solubility in aqueous environments, and can be readily derivatized with sensor components. The trigger was swapped in a one-pot method, which is promising for the rapid production of a series of sensors.

SUBMITTER: Powers LA

PROVIDER: S-EPMC6274001 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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A Versatile Axle for the Construction of Disassemblage Rotaxanes.

Powers Lucas A LA Smithrud David B DB

Molecules (Basel, Switzerland) 20160810 8

Rotaxanes are unique mechanical devices that hold great promise as sensors. We report on two new rotaxanes that contain an acid or base sensitive trigger and readily disassemble in a wide range of environments. Disassemblage was observed under TLC and ¹H-NMR analysis. The axle is highly charged, which enhances solubility in aqueous environments, and can be readily derivatized with sensor components. The trigger was swapped in a one-pot method, which is promising for the rapid production of a ser ...[more]

PMID: 27517897

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Accelerating the Shuttling in Hydrogen-Bonded Rotaxanes: Active Role of the Axle and the End Station.

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