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Biotransformation of Resveratrol: New Prenylated trans-Resveratrol Synthesized by Aspergillus sp. SCSIOW2.

ABSTRACT: Arahypin-16 (1), a new prenylated resveratrol with a unique dihydrobenzofuran ring, has been isolated as a microbial metabolite of resveratrol (2) from whole-cell fermentation of Aspergillus sp. SCSIOW2. The stereochemistry of 1 was determined by ECD calculations. 1 showed about half of the extracellular radical scavenging effect (IC50 = 161.4 ?M) compared with resveratrol (IC50 = 80.5 ?M), while on biomembranes it exhibited the same range of protection effects against free radicals generated from AAPH (IC50 = 78.6 ?M and 87.9 ?M).

SUBMITTER: Wang L

PROVIDER: S-EPMC6274042 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Biotransformation of Resveratrol: New Prenylated trans-Resveratrol Synthesized by Aspergillus sp. SCSIOW2.

Wang Liyan L Wu Yanhua Y Chen Yongtao Y Zou Jiaxin J Li Xiaofan X

Molecules (Basel, Switzerland) 20160706 7

Arahypin-16 (1), a new prenylated resveratrol with a unique dihydrobenzofuran ring, has been isolated as a microbial metabolite of resveratrol (2) from whole-cell fermentation of Aspergillus sp. SCSIOW2. The stereochemistry of 1 was determined by ECD calculations. 1 showed about half of the extracellular radical scavenging effect (IC50 = 161.4 μM) compared with resveratrol (IC50 = 80.5 μM), while on biomembranes it exhibited the same range of protection effects against free radicals generated fr ...[more]

PMID: 27399656

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