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New Prenylated Indole Homodimeric and Pteridine Alkaloids from the Marine-Derived Fungus Aspergillus austroafricanus Y32-2.


ABSTRACT: Chemical investigation of secondary metabolites from the marine-derived fungus Aspergillus austroafricanus Y32-2 resulted in the isolation of two new prenylated indole alkaloid homodimers, di-6-hydroxydeoxybrevianamide E (1) and dinotoamide J (2), one new pteridine alkaloid asperpteridinate A (3), with eleven known compounds (4-14). Their structures were elucidated by various spectroscopic methods including HRESIMS and NMR, while their absolute configurations were determined by ECD calculations. Each compound was evaluated for pro-angiogenic, anti-inflammatory effects in zebrafish models and cytotoxicity for HepG2 human liver carcinoma cells. As a result, compounds 2, 4, 5, 7, 10 exhibited pro-angiogenic activity in a PTK787-induced vascular injury zebrafish model in a dose-dependent manner, compounds 7, 8, 10, 11 displayed anti-inflammatory activity in a CuSO4-induced zebrafish inflammation model, and compound 6 showed significant cytotoxicity against HepG2 cells with an IC50 value of 30 µg/mL.

SUBMITTER: Li P 

PROVIDER: S-EPMC7916005 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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New Prenylated Indole Homodimeric and Pteridine Alkaloids from the Marine-Derived Fungus <i>Aspergillus austroafricanus</i> Y32-2.

Li Peihai P   Zhang Mengqi M   Li Haonan H   Wang Rongchun R   Hou Hairong H   Li Xiaobin X   Liu Kechun K   Chen Hao H  

Marine drugs 20210209 2


Chemical investigation of secondary metabolites from the marine-derived fungus <i>Aspergillus austroafricanus</i> Y32-2 resulted in the isolation of two new prenylated indole alkaloid homodimers, di-6-hydroxydeoxybrevianamide E (<b>1</b>) and dinotoamide J (<b>2</b>), one new pteridine alkaloid asperpteridinate A (<b>3</b>), with eleven known compounds (<b>4</b>-<b>14</b>). Their structures were elucidated by various spectroscopic methods including HRESIMS and NMR, while their absolute configura  ...[more]

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