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Anti-Inflammatory Effects of 6,8-Diprenyl-7,4'-dihydroxyflavanone from Sophora tonkinensis on Lipopolysaccharide-Stimulated RAW 264.7 Cells.

ABSTRACT: The anti-inflammatory effects and molecular mechanism of 6,8-diprenyl-7,4'-dihydroxyflavanone (DDF), one of the flavanones found in Sophora tonkinensis, were assessed in vitro through macrophage-mediated inflammation in the present study. The anti-inflammatory effects of DDF were not previously reported. DDF inhibited the production of nitric oxide and the expression of tumor necrosis factor ?, interleukin-1?, and interleukin-6. Furthermore, the activation of nuclear factor-?B (NF-?B) and extracellular signal-regulated kinases (ERKs) in lipopolysaccharide-stimulated macrophages was suppressed by treatment with DDF. Therefore, DDF demonstrated potentially anti-inflammatory effects via the blockade of NF-?B and ERK activation in macrophages.

SUBMITTER: Chae HS

PROVIDER: S-EPMC6274169 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Anti-Inflammatory Effects of 6,8-Diprenyl-7,4'-dihydroxyflavanone from Sophora tonkinensis on Lipopolysaccharide-Stimulated RAW 264.7 Cells.

Chae Hee-Sung HS Yoo Hunseung H Kim Young-Mi YM Choi Young Hee YH Lee Chang Hoon CH Chin Young-Won YW

Molecules (Basel, Switzerland) 20160811 8

The anti-inflammatory effects and molecular mechanism of 6,8-diprenyl-7,4'-dihydroxyflavanone (DDF), one of the flavanones found in Sophora tonkinensis, were assessed in vitro through macrophage-mediated inflammation in the present study. The anti-inflammatory effects of DDF were not previously reported. DDF inhibited the production of nitric oxide and the expression of tumor necrosis factor α, interleukin-1β, and interleukin-6. Furthermore, the activation of nuclear factor-κB (NF-κB) and extrac ...[more]

PMID: 27529198

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