Ontology highlight
ABSTRACT:
SUBMITTER: de Freitas Silva M
PROVIDER: S-EPMC7397262 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20200710 14
<i>Alzheimer's disease</i> (AD) is a <i>multifactorial</i> neurodegenerative disorder that involves different pathogenic mechanisms. In this regard, the goal of this study was the design and synthesis of new compounds with multifunctional pharmacological activity by molecular hybridization of structural fragments of curcumin and resveratrol connected by an <i>N-</i>acyl-hydrazone function linked to a 1,4-disubstituted triazole system. Among these hybrid compounds, derivative <b>3e</b> showed the ...[more]