Photoinduced Ligand Release from a Silicon Phthalocyanine Dye Conjugated with Monoclonal Antibodies: A Mechanism of Cancer Cell Cytotoxicity after Near-Infrared Photoimmunotherapy.
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ABSTRACT:
SUBMITTER: Sato K
PROVIDER: S-EPMC6276043 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
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Photoinduced Ligand Release from a Silicon Phthalocyanine Dye Conjugated with Monoclonal Antibodies: A Mechanism of Cancer Cell Cytotoxicity after Near-Infrared Photoimmunotherapy.
Sato Kazuhide K Ando Kanta K Okuyama Shuhei S Moriguchi Shiho S Ogura Tairo T Totoki Shinichiro S Hanaoka Hirofumi H Nagaya Tadanobu T Kokawa Ryohei R Takakura Hideo H Nishimura Masayuki M Hasegawa Yoshinori Y Choyke Peter L PL Ogawa Mikako M Kobayashi Hisataka H
ACS central science 20181106 11
Photochemical reactions can dramatically alter physical characteristics of reacted molecules. In this study, we demonstrate that near-infrared (NIR) light induces an axial ligand-releasing reaction, which dramatically alters hydrophilicity of a silicon phthalocyanine derivative (IR700) dye leading to a change in the shape of the conjugate and its propensity to aggregate in aqueous solution. This photochemical reaction is proposed as a major mechanism of cell death induced by NIR photoimmunothera ...[more]
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