Ontology highlight
ABSTRACT:
SUBMITTER: Long L
PROVIDER: S-EPMC6276372 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20180125 5
An ability to visualize HCN in mitochondria in real time may permit additional insights into the critical toxicological and physiological roles this classic toxin plays in living organisms. Herein, we report a mitochondria-specific coumarin pyrrolidinium-derived fluorescence probe (MRP1) that permits the real-time ratiometric imaging of HCN in living cells. The response is specific, sensitive (detection limit is ca. 65.6 nM), rapid (within 1 s), and reversible. Probe MRP1 contains a benzyl chlor ...[more]