Oncogenic regulatory circuits driven by 19q13 rs11672691 underlies prostate cancer aggressiveness.
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ABSTRACT:
SUBMITTER: Xia JH
PROVIDER: S-EPMC6276850 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Oncogenic regulatory circuits driven by 19q13 rs11672691 underlies prostate cancer aggressiveness.
Xia Ji-Han JH Wei Gong-Hong GH
Molecular & cellular oncology 20180920 6
The 19q13 allele rs11672691 has been reproducibly found in association with aggressive form of prostate cancer, yet the underlying mechanism remains totally unknown. We have recently uncovered a mechanism by which rs11672691 influenced a novel oncogenic regulatory circuit, including HOXA2, <i>PCAT19</i> and <i>CEACAM21</i>, thereby contributing to prostate cancer aggressiveness. ...[more]
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