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Oncogenic regulatory circuits driven by 19q13 rs11672691 underlies prostate cancer aggressiveness.

ABSTRACT: The 19q13 allele rs11672691 has been reproducibly found in association with aggressive form of prostate cancer, yet the underlying mechanism remains totally unknown. We have recently uncovered a mechanism by which rs11672691 influenced a novel oncogenic regulatory circuit, including HOXA2, PCAT19 and CEACAM21, thereby contributing to prostate cancer aggressiveness.

SUBMITTER: Xia JH 

PROVIDER: S-EPMC6276850 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Oncogenic regulatory circuits driven by 19q13 rs11672691 underlies prostate cancer aggressiveness.

Xia Ji-Han JH   Wei Gong-Hong GH  

Molecular & cellular oncology 20180920 6

The 19q13 allele rs11672691 has been reproducibly found in association with aggressive form of prostate cancer, yet the underlying mechanism remains totally unknown. We have recently uncovered a mechanism by which rs11672691 influenced a novel oncogenic regulatory circuit, including HOXA2, <i>PCAT19</i> and <i>CEACAM21</i>, thereby contributing to prostate cancer aggressiveness. ...[more]

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