Ontology highlight
ABSTRACT:
SUBMITTER: Zheng SC
PROVIDER: S-EPMC6277016 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Zheng Shijie C SC Breeze Charles E CE Beck Stephan S Teschendorff Andrew E AE
Nature methods 20181130 12
An outstanding challenge of epigenome-wide association studies (EWASs) performed in complex tissues is the identification of the specific cell type(s) responsible for the observed differential DNA methylation. Here we present a statistical algorithm called CellDMC ( https://github.com/sjczheng/EpiDISH ), which can identify differentially methylated positions and the specific cell type(s) driving the differential methylation. We validated CellDMC on in silico mixtures of DNA methylation data gene ...[more]