Ontology highlight
ABSTRACT:
SUBMITTER: Bu J
PROVIDER: S-EPMC6277029 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Bu J J Chen A A Yan X X He F F Dong Y Y Zhou Y Y He J J Zhan D D Lin P P Hayashi Y Y Sun Y Y Zhang Y Y Xiao Z Z Grimes H L HL Wang Q F QF Huang G G
Leukemia 20171129 4
Previously, we identified SETD2 loss-of-function mutations in 22% of MLL-rearranged (MLLr) acute leukemia patients, implicating a mechanism for cooperativity between SETD2 mutations and MLL fusions. However, the detailed mechanism of how SETD2-H3K36me3 downregulation accelerates MLLr leukemia remains unclear. Here, we show that in MLLr leukemia, both H3K79me2 and H3K36me3 are aberrantly elevated and co-enriched in a group of genes. SETD2 inactivation leads to a global reduction of H3K36me3 and a ...[more]