Ontology highlight
ABSTRACT:
SUBMITTER: Skucha A
PROVIDER: S-EPMC5959866 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Skucha Anna A Ebner Jessica J Schmöllerl Johannes J Roth Mareike M Eder Thomas T César-Razquin Adrián A Stukalov Alexey A Vittori Sarah S Muhar Matthias M Lu Bin B Aichinger Martin M Jude Julian J Müller André C AC Győrffy Balázs B Vakoc Christopher R CR Valent Peter P Bennett Keiryn L KL Zuber Johannes J Superti-Furga Giulio G Grebien Florian F
Nature communications 20180518 1
MLL-fusions represent a large group of leukemia drivers, whose diversity originates from the vast molecular heterogeneity of C-terminal fusion partners of MLL. While studies of selected MLL-fusions have revealed critical molecular pathways, unifying mechanisms across all MLL-fusions remain poorly understood. We present the first comprehensive survey of protein-protein interactions of seven distantly related MLL-fusion proteins. Functional investigation of 128 conserved MLL-fusion-interactors ide ...[more]