Ontology highlight
ABSTRACT:
SUBMITTER: Calcinotto A
PROVIDER: S-EPMC6277390 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Nature communications 20181203 1
The gut microbiota has been causally linked to cancer, yet how intestinal microbes influence progression of extramucosal tumors is poorly understood. Here we provide evidence implying that Prevotella heparinolytica promotes the differentiation of Th17 cells colonizing the gut and migrating to the bone marrow (BM) of transgenic Vk*MYC mice, where they favor progression of multiple myeloma (MM). Lack of IL-17 in Vk*MYC mice, or disturbance of their microbiome delayed MM appearance. Similarly, in s ...[more]