Ontology highlight
ABSTRACT:
SUBMITTER: Sun W
PROVIDER: S-EPMC6277442 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Nature communications 20181203 1
The function of B cells in osteoblast (OB) dysfunction in rheumatoid arthritis (RA) has not been well-studied. Here we show that B cells are enriched in the subchondral and endosteal bone marrow (BM) areas adjacent to osteocalcin<sup>+</sup> OBs in two murine RA models: collagen-induced arthritis and the TNF-transgenic mice. Subchondral BM B cells in RA mice express high levels of OB inhibitors, CCL3 and TNF, and inhibit OB differentiation by activating ERK and NF-κB signaling pathways. The inhi ...[more]