Ontology highlight
ABSTRACT:
SUBMITTER: Carvajal G
PROVIDER: S-EPMC6277452 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Carvajal Guillermo G Brukman Nicolás Gastón NG Weigel Muñoz Mariana M Battistone María A MA Guazzone Vanesa A VA Ikawa Masahito M Haruhiko Miyata M Lustig Livia L Breton Sylvie S Cuasnicu Patricia S PS
Scientific reports 20181203 1
Epididymal Cysteine Rich Secretory Proteins 1 and 4 (CRISP1 and CRISP4) associate with sperm during maturation and play different roles in fertilization. However, males lacking each of these molecules individually are fertile, suggesting compensatory mechanisms between these homologous proteins. Based on this, in the present work, we generated double CRISP1/CRISP4 knockout (DKO) mice and examined their reproductive phenotype. Our data showed that the simultaneous lack of the two epididymal prote ...[more]