Ontology highlight
ABSTRACT:
SUBMITTER: Abe Y
PROVIDER: S-EPMC6277683 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Abe Yuichi Y Honsho Masanori M Itoh Ryota R Kawaguchi Ryoko R Fujitani Masashi M Fujiwara Kazushirou K Hirokane Masaaki M Matsuzaki Takashi T Nakayama Keiko K Ohgi Ryohei R Marutani Toshihiro T Nakayama Keiichi I KI Yamashita Toshihide T Fujiki Yukio Y
Life science alliance 20181203 6
Peroxisome biogenesis disorders (PBDs) manifest as neurological deficits in the central nervous system, including neuronal migration defects and abnormal cerebellum development. However, the mechanisms underlying pathogenesis remain enigmatic. Here, to investigate how peroxisome deficiency causes neurological defects of PBDs, we established a new PBD model mouse defective in peroxisome assembly factor Pex14p, termed <i>Pex14</i> <sup><i>ΔC/ΔC</i></sup> mouse. <i>Pex14</i> <sup><i>ΔC/ΔC</i></sup> ...[more]