Ontology highlight
ABSTRACT:
SUBMITTER: Kang SM
PROVIDER: S-EPMC6768106 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
FEBS open bio 20190820 10
Transcriptional regulator proteins are closely involved in essential survival strategies in bacteria. AcrR is a one-component allosteric repressor of the genes associated with lipid transport and antibiotic resistance. When fatty acid ligands bind to the C-terminal ligand-binding cavity of AcrR, a conformational change in the N-terminal operator-binding region of AcrR is triggered, which releases the repressed DNA and initiates transcription. This paper focuses on the structural transition mecha ...[more]