Lipoprotein(a) and Cardiovascular Risk Prediction Among Women.

ABSTRACT:

Background

Although lipoprotein(a) [Lp(a)] is associated with incident cardiovascular disease (CVD), its contribution to prediction remains controversial.

Objectives

This study examined the association and clinical utility of Lp(a) with incident CVD in women.

Methods

A turbidimetric assay assessed Lp(a) in 3 cohorts of women (the WHS [Women's Health Study] [N = 24,558], a case-cohort sample from the WHI [Women's Health Initiative] Observational Study [n = 1,815 cases, subcohort n = 1,989], and the JUPITER [Justification for Use of Statins in Prevention] trial [n = 2,569]) and in men from JUPITER (n = 5,161). A WHS derivation sample (n = 16,400) determined the form of association with incident CVD. This was tested in WHS validation data (n = 8,158) and the other study

SUBMITTER: Cook NR 

PROVIDER: S-EPMC6277983 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature