Ontology highlight
ABSTRACT:
SUBMITTER: de Paula RL
PROVIDER: S-EPMC6278417 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
de Paula Reuel L RL de Almeida Joyce S F D JSFD Cavalcante Samir F A SFA Gonçalves Arlan S AS Simas Alessandro B C ABC Franca Tanos C C TCC Valis Martin M Kuca Kamil K Nepovimova Eugenie E Granjeiro José M JM
Molecules (Basel, Switzerland) 20181112 11
The present work aimed to compare the small, neutral and monoaromatic oxime, isatin-3-oxime (isatin-O), to the commercial ones, pralidoxime (2-PAM) and obidoxime, in a search for a new potential reactivator for acetylcholinesterase (AChE) inhibited by the pesticide paraoxon (AChE/POX) as well as a novel potential scaffold for further synthetic modifications. The multicriteria decision methods (MCDM) allowed the identification of the best docking poses of those molecules inside AChE/POX for furth ...[more]