Ontology highlight
ABSTRACT:
SUBMITTER: Kuca K
PROVIDER: S-EPMC5822599 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
BMC pharmacology & toxicology 20180221 1
<h4>Background</h4>Based on in vitro and in vivo rat experiments, the newly developed acetylcholinesterase (AChE) reactivator, K203, appears to be much more effective in the treatment of tabun poisonings than currently fielded oximes.<h4>Methods</h4>To determine if this reactivating efficacy would extend to humans, studies were conducted in vitro using human brain homogenate as the source of AChE. The efficacy of K203 was compared with commercially available oximes; pralidoxime, obidoxime and as ...[more]