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Synthesis of 1-(para-methoxyphenyl)tetrazolyl-Substituted 1,2,3,4-Tetrahydroisoquinolines and Their Transformations Involving Activated Alkynes.


ABSTRACT: 1-(p-Methoxyphenyl)tetrazolyl-substituted 6,7-dimethoxy(6,7-methylenedioxy)-1,2,3,4-tetrahydroisoquinolines formed tetrazolyl-substituted azocines in high yields by using activated alkynes. Unsubstituted at 6,7,8-aromatic fragment 1-tetrazolylisoquinoline interacted in several pathways forming tetrazolyl-substituted azocines, 1-tetrazolyl-1-R-vinylisoquinolines and 3-azaspiro[5.5]undeca-1,7,9-triene.

SUBMITTER: Titov AA 

PROVIDER: S-EPMC6278526 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Synthesis of 1-(<i>para</i>-methoxyphenyl)tetrazolyl-Substituted 1,2,3,4-Tetrahydroisoquinolines and Their Transformations Involving Activated Alkynes.

Titov Alexander A AA   Samavati Reza R   Alexandrova Elena V EV   Borisova Tatiana N TN   Dang Thi Tuyet Anh TA   Nguyen Van Tuyen VT   Le Tuan Anh TA   Varlamov Alexey V AV   Van der Eycken Erik V EV   Voskressensky Leonid G LG  

Molecules (Basel, Switzerland) 20181117 11


1-(<i>p</i>-Methoxyphenyl)tetrazolyl-substituted 6,7-dimethoxy(6,7-methylenedioxy)-1,2,3,4-tetrahydroisoquinolines formed tetrazolyl-substituted azocines in high yields by using activated alkynes. Unsubstituted at 6,7,8-aromatic fragment 1-tetrazolylisoquinoline interacted in several pathways forming tetrazolyl-substituted azocines, 1-tetrazolyl-1-R-vinylisoquinolines and 3-azaspiro[5.5]undeca-1,7,9-triene. ...[more]

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