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Synthesis of indole-cycloalkyl[b]pyridine hybrids via a four-component six-step tandem process.

ABSTRACT: The one-pot four-component reaction of 3-(1H-indol-3-yl)-3-oxopropanenitriles, aromatic aldehydes, cycloalkanones and ammonium acetate occurred via a six-step tandem Knoevenagel condensation-nucleophilic addition to carbonyl-Michael addition-N-cyclization-elimination-air oxidation sequence to afford structurally intriguing indole-cycloalkyl[b]pyridine-3-carbonitrile hybrid heterocycles in excellent yields.

SUBMITTER: Muthu M

PROVIDER: S-EPMC6278771 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Synthesis of indole-cycloalkyl[b]pyridine hybrids via a four-component six-step tandem process.

Muthu Muthumani M Vishnu Priya Rakkappan R Almansour Abdulrahman I AI Suresh Kumar Raju R Kumar Raju Ranjith RR

Beilstein journal of organic chemistry 20181122

The one-pot four-component reaction of 3-(1H-indol-3-yl)-3-oxopropanenitriles, aromatic aldehydes, cycloalkanones and ammonium acetate occurred via a six-step tandem Knoevenagel condensation-nucleophilic addition to carbonyl-Michael addition-N-cyclization-elimination-air oxidation sequence to afford structurally intriguing indole-cycloalkyl[b]pyridine-3-carbonitrile hybrid heterocycles in excellent yields. ...[more]

PMID: 30546474

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