Ontology highlight
ABSTRACT:
SUBMITTER: D'Ignazio L
PROVIDER: S-EPMC6279113 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
D'Ignazio Laura L Michel Marc M Beyer Melissa M Thompson Kassimier K Forabosco Antonino A Schlessinger David D Pelosi Emanuele E
Biology of reproduction 20180401 4
Following proliferation of oogonia in mammals, great numbers of germ cells are discarded, primarily by apoptosis, while the remainder form primordial follicles (the ovarian reserve) that determine fertility and reproductive lifespan. More massive, rapid, and essentially total loss of oocytes, however, occurs when the transcription factor Lhx8 is ablated-though the cause and mechanism of germ cell loss from the Lhx8-/- ovaries has been unknown. We found that Lhx8-/- ovaries maintain the same numb ...[more]