Ontology highlight
ABSTRACT:
SUBMITTER: Rinaldi VD
PROVIDER: S-EPMC5621520 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Rinaldi Vera D VD Bolcun-Filas Ewelina E Kogo Hiroshi H Kurahashi Hiroki H Schimenti John C JC
Molecular cell 20170824 6
Pairing and synapsis of homologous chromosomes during meiosis is crucial for producing genetically normal gametes and is dependent upon repair of SPO11-induced double-strand breaks (DSBs) by homologous recombination. To prevent transmission of genetic defects, diverse organisms have evolved mechanisms to eliminate meiocytes containing unrepaired DSBs or unsynapsed chromosomes. Here we show that the CHK2 (CHEK2)-dependent DNA damage checkpoint culls not only recombination-defective mouse oocytes ...[more]