Dataset Information

Plasma endothelin-1 levels are increased in atrial fibrillation patients with hyperthyroidism.

ABSTRACT:

Background

Endothelin-1 (ET-1) is a potent vasoconstrictor, mitogen and inflammatory factor that may contribute to development of atrial fibrillation (AF). Plasma ET-1 levels are increased in hyperthyroid patients, but studies evaluating its relation to AF development in hyperthyroid patients are lacking.

Objective

The present study seeks to evaluate the relation of plasma ET-1 to AF development as a function of thyroid status.

Methods

Blood samples from euthyroid patients (n = 41), hypothyroid (n = 61), hyperthyroid (n = 41), AF with hyperthyroidism (n = 9), and euthyroid AF (n = 10) patients were collected. Plasma ET-1, CRP, and thyroid hormone levels were measured and compared between groups.