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Elevated plasma levels of Th17-related cytokines are associated with increased risk of atrial fibrillation.


ABSTRACT: We performed a matched case-control study using a propensity score matching, to assess the association of Th17-related cytokines, including interleukin (IL) 17A (IL-17A), IL-17F, IL-21, IL-22 and IL-6, along with interferon-? (IFN-?), IL-10, IL-9, and IL-4, with the risk of AF. A total of 336 patients with AF were matched 1:1 with patients without AF. Plasma levels of cytokines were measured using Luminex xMAP assays. The plasma levels of all examined cytokines were significantly higher in AF patients than controls (P?

SUBMITTER: Wu N 

PROVIDER: S-EPMC4873818 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Elevated plasma levels of Th17-related cytokines are associated with increased risk of atrial fibrillation.

Wu Na N   Xu Bin B   Liu Yuan Y   Chen Xinghua X   Tang He H   Wu Long L   Xiang Ying Y   Zhang Mengxuan M   Shu Maoqing M   Song Zhiyuan Z   Li Yafei Y   Zhong Li L  

Scientific reports 20160520


We performed a matched case-control study using a propensity score matching, to assess the association of Th17-related cytokines, including interleukin (IL) 17A (IL-17A), IL-17F, IL-21, IL-22 and IL-6, along with interferon-γ (IFN-γ), IL-10, IL-9, and IL-4, with the risk of AF. A total of 336 patients with AF were matched 1:1 with patients without AF. Plasma levels of cytokines were measured using Luminex xMAP assays. The plasma levels of all examined cytokines were significantly higher in AF pa  ...[more]

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