Ontology highlight
ABSTRACT:
SUBMITTER: Bezu L
PROVIDER: S-EPMC6279318 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Bezu Lucillia L Kepp Oliver O Cerrato Giulia G Pol Jonathan J Fucikova Jitka J Spisek Radek R Zitvogel Laurence L Kroemer Guido G Galluzzi Lorenzo L
Oncoimmunology 20180906 12
Peptide-based anticancer vaccination aims at stimulating an immune response against one or multiple tumor-associated antigens (TAAs) following immunization with purified, recombinant or synthetically engineered epitopes. Despite high expectations, the peptide-based vaccines that have been explored in the clinic so far had limited therapeutic activity, largely due to cancer cell-intrinsic alterations that minimize antigenicity and/or changes in the tumor microenvironment that foster immunosuppres ...[more]