Trial watch: Naked and vectored DNA-based anticancer vaccines.
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ABSTRACT:
SUBMITTER: Bloy N
PROVIDER: S-EPMC4485755 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Publications
Trial watch: Naked and vectored DNA-based anticancer vaccines.
Bloy Norma N Buqué Aitziber A Aranda Fernando F Castoldi Francesca F Eggermont Alexander A Cremer Isabelle I Sautès-Fridman Catherine C Fucikova Jitka J Galon Jérôme J Spisek Radek R Tartour Eric E Zitvogel Laurence L Kroemer Guido G Galluzzi Lorenzo L
Oncoimmunology 20150402 5
One type of anticancer vaccine relies on the administration of DNA constructs encoding one or multiple tumor-associated antigens (TAAs). The ultimate objective of these preparations, which can be naked or vectored by non-pathogenic viruses, bacteria or yeast cells, is to drive the synthesis of TAAs in the context of an immunostimulatory milieu, resulting in the (re-)elicitation of a tumor-targeting immune response. In spite of encouraging preclinical results, the clinical efficacy of DNA-based v ...[more]
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