Trial Watch: Oncolytic viro-immunotherapy of hematologic and solid tumors.
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ABSTRACT:
SUBMITTER: Pol JG
PROVIDER: S-EPMC6279343 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Trial Watch: Oncolytic viro-immunotherapy of hematologic and solid tumors.
Pol Jonathan G JG Lévesque Sarah S Workenhe Samuel T ST Gujar Shashi S Le Boeuf Fabrice F Clements Derek R DR Fahrner Jean-Eudes JE Fend Laetitia L Bell John C JC Mossman Karen L KL Fucikova Jitka J Spisek Radek R Zitvogel Laurence L Kroemer Guido G Galluzzi Lorenzo L
Oncoimmunology 20180827 12
Oncolytic viruses selectively target and kill cancer cells in an immunogenic fashion, thus supporting the establishment of therapeutically relevant tumor-specific immune responses. In 2015, the US Food and Drug Administration (FDA) approved the oncolytic herpes simplex virus T-VEC for use in advanced melanoma patients. Since then, a plethora of trials has been initiated to assess the safety and efficacy of multiple oncolytic viruses in patients affected with various malignancies. Here, we summar ...[more]
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