Combination Immunotherapy Using Oncolytic Virus for the Treatment of Advanced Solid Tumors.
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ABSTRACT:
SUBMITTER: Oh CM
PROVIDER: S-EPMC7589893 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
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Combination Immunotherapy Using Oncolytic Virus for the Treatment of Advanced Solid Tumors.
Oh Chang-Myung CM Chon Hong Jae HJ Kim Chan C
International journal of molecular sciences 20201019 20
Oncolytic virus (OV) is a new therapeutic strategy for cancer treatment. OVs can selectively infect and destroy cancer cells, and therefore act as an in situ cancer vaccine by releasing tumor-specific antigens. Moreover, they can remodel the tumor microenvironment toward a T cell-inflamed phenotype by stimulating widespread host immune responses against the tumor. Recent evidence suggests several possible applications of OVs against cancer, especially in combination with immune checkpoint inhibi ...[more]
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