Ontology highlight
ABSTRACT:
SUBMITTER: Liu XM
PROVIDER: S-EPMC6279349 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
eLife 20181119
The ubiquitin-like protein Atg8, in its lipidated form, plays central roles in autophagy. Yet, remarkably, Atg8 also carries out lipidation-independent functions in non-autophagic processes. How Atg8 performs its moonlighting roles is unclear. Here we report that in the fission yeast <i>Schizosaccharomyces pombe</i> and the budding yeast <i>Saccharomyces cerevisiae</i>, the lipidation-independent roles of Atg8 in maintaining normal morphology and functions of the vacuole require its interaction ...[more]